The Blue Islands flight will launch on May 2 and operate three times a week on Tuesdays, Thursdays and Sundays. One-way flights lead in at £39.99.
Debra Barber, managing director and chief operating officer at Cardiff airport, said: “It’s great to welcome another airline to Cardiff Airport.
“The franchise agreement between Blue Islands and Flybe is an innovative way to offer our customers even more choice and value for money, as demonstrated by the introduction of a new service to Guernsey.
“The island offers visitors a unique experience and boasts stunning scenery, and with three departures a week it’s ideal for a short, relaxing break.