The Blue Islands flight will launch on May 2 and operate three times a week on Tuesdays, Thursdays and Sundays. One-way flights lead in at £39.99.
Debra Barber, managing director and chief operating officer at Cardiff airport, said: “It’s great to welcome another airline to Cardiff Airport.
“The franchise agreement between Blue Islands and Flybe is an innovative way to offer our customers even more choice and value for money, as demonstrated by the introduction of a new service to Guernsey.
“The island offers visitors a unique experience and boasts stunning scenery, and with three departures a week it’s ideal for a short, relaxing break.
“Additionally this offers residents the perfect opportunity to visit Wales and to discover all that our stunning country has to offer.”
Rob Veron, Blue Islands chief executive, added: “Blue Islands is committed to the rejuvenation of our tourism industry and we hope this new route will be a valuable boost to our island’s visitor economy.
“With the added benefit of our Flybe franchise, Blue Islands is also better equipped than ever to encourage the 1.8 million audience surrounding Cardiff Airport to discover our beautiful island.”
"We are working closely with Visit Guernsey, Visit Wales, Guernsey and Cardiff airports. As well as attracting new visitors to Guernsey, with a flight time of just one hour, this new service provides islanders with an exciting new direct destination, perfect for city breaks.
“Cardiff offers wonderful shopping, heritage, world-class entertainment and of course the gateway to discovering south Wales and all that this stunning region has to offer.”