Daily flights between East Midlands and Southampton to Paris Orly will commence on 14 April, and from Cardiff on 21 April.
The move will also see Eastern Airways return to East Midlands as a base carrier, adding around 25 crew and engineering roles.
"We are delighted to be entering into this cooperation with Air France and opening up connectivity to Europe’s second biggest city for both business and leisure travelers and restoring direct access year-round to France," said Roger Hage, commercial director for Eastern Airways.
The new service will operate on a low-emission 72-seat ATR aircraft, the first to be based at East-Midlands airport for Eastern Airways.
This will complement the Newquay-Cornwall service which launches on 31 March and will act as a catalyst to further new services from the East Midlands hub.
