New destinations include Santorini, Chania, Corsica, Lisbon, Antalya and Izmir, as well as city connections to Amsterdam from Southend, Glasgow to Lisbon, Birmingham to Naples and a year-round Manchester-Paris service.
The airline will also reintroduce flights from Gatwick to Ancona, with a twice-weekly service operating on Mondays and Fridays from 26 June, with prices from £28.99pp. Twice-weekly Calvi flights from the London airport will launch on 28 June with prices from £42.89pp.
Elsewhere, Luton to Izmir services will operate twice-weekly on Mondays and Saturdays from 3 April with fares from £41.99pp, and Southend to Amsterdam routes will operate twice weekly on Mondays and Saturdays from 24 May with fares from £22.99pp.
Bristol to Chania flights will operate twice weekly on Tuesdays and Saturdays from 27 June with fares from £32.99pp, twice-weekly Birmingham-Naples flights will operate from 1 April from £26.99pp and five-times weekly Manchester-Paris services will launch on 27 March with fares from £22.99pp.
In Edinburgh, flights to Antalya will operate twice-weekly on Wednesdays and Saturdays from 3 June and services to Santorini will operate on Tuesdays from 6 June from £39.99pp.
Glasgow to Lisbon flights will operate twice-weekly on Tuesdays and Saturdays from 2 June with fares from £39.99pp and Belfast to Antalya will operate twice-weekly on Wednesdays and Sundays from 26 March with fares from £37.99pp.
Ali Gayward, easyJet’s UK country manager said: "We remain committed to strengthening our unrivalled short-haul network and providing affordable and convenient connections for our customers across the UK, all with great-value fares and the warm welcome that our crew are famous for."