The bulk of up to 530 flights per week are from Birmingham and Belfast City and are domestic, but flights from Belfast City, Birmingham, East Midlands and Heathrow to Amsterdam also feature. Flybe will also operate from Heathrow to Belfast City.
In addition, there are also summer-only flights from Birmingham to Avignon and Brest, as well as Southampton to Avignon and Toulon. Fares will start at £29.99 one-way on 15 domestic routes.
Flybe chief executive Dave Pflieger said: “We are delighted to now be out for sale and starting service next month.