The trade-only firm’s expanded product range will be available to book from 28 November.
The offering will feature destinations such as Cape Town; the Winelands; the Eastern Cape; Kruger and Greater Kruger National Parks; Johannesburg; KwaZulu Natal; Madikwe; and The Garden Route.
The company has also added more than 50 hotels to their portfolio, as well as a number of day tours and private excursions.
The programme will feature properties such as One&Only Cape Town; Babylonstoren; Mont Rochelle; and Kensington Place.
Gordon McCreadie, general manager of If Only, said: "Our expansion into this region has been integral to our very focused development plans.