Sykes, who has previously represented Norwegian Cruise Line and Sandals Resorts, will take on responsibility for agents in the north of England and Scotland.
She will take up her new role on Tuesday (14 March) reporting to UK sales director John Fair.
Her remit will be to manage existing, and build new, relationships with trade and industry partners, support the business in delivering strategy and core initiatives, identify new opportunities and support the business at all levels with new lead generation.
Sykes has previously held roles with Virgin rains East Coast and online marketing company Living Social (Escapes), and brings 25 years’ travel industry BDM experience to the role.
"I’m delighted to be joining the CroisiEurope team at such an exciting time, with the launch of the brand new call centre and the ability to offer Atol-protected fly/cruise packages for the first time," said Sykes.
"I look forward to working closely with our trade partners in the north and helping drive forward CroisiEurope’s growth plans.”
Fair added: “Janine’s appointment clearly demonstrates our continued commitment, not only to growing the business, but to investing in the UK and supporting our agent partners in northern England and Scotland.
"I’m delighted to welcome Janine onboard and am confident that her vast experience, energy and passion for the travel industry will prove invaluable."