The flights saw the start of the airline and operator’s flights and city breaks to the cities for summer 2023 to the end of November.
Twice-weekly services on Thursdays and Sundays will operate to Athens from Stansted until 26 November, while four-weekly services on Mondays, Thursdays, Fridays and Sundays are available to Rome until 27 November.
When travelling to Athens or Rome, customers can choose from a flight-only or a package option with Jet2CityBreaks available for £60pp deposit.
Steve Heapy, chief executive of Jet2.com and Jet2holidays, said: "Since putting services on sale to these two destinations from Stansted, local customers and independent travel agents have been booking getaways to the city break hotspots in their numbers.
"With 42 sun and city destinations on sale this summer from the base, we pleased to be offering an unrivalled flying programme for summer 2023."