Jet2CityBreaks has restarted its programme from Manchester with flights to Barcelona and Rome.
More destinations will be added in the winter, including Reykjavik, Budapest, Prague, Vienna and a selection of Christmas Markets trips.
Steve Heapy, chief of Jet2.com and Jet2CityBreaks, said the demand for city breaks is returning "very strongly" and comes at "the perfect time to get away".
"The restart of our award-winning city breaks programme is another step towards a real and meaningful restart of international travel," he added.
"We still have some way to go, but we are looking ahead with real confidence and optimism as we know how much customers want to get away and enjoy themselves."