The increase comes in response to "strong demand" from the airline’s and operator’s customers.
There will be extra Tuesday services added to Kefalonia from Newcastle from 26 July to 30 August 2022 and new Wednesday services to Zante from 27 July and 30 August 2022.
New Monday services to Corfu from 25 July to 29 August 2022 will also be added.
A new route to Malta from Bristol, with weekly Tuesday services operating from 31 May and 25 October 2022, will be made available.
Thursday services will be added to Kefalonia from 26 May through to 22 September 2022, new weekly Friday services to Larnaca from 27 May to 28 October 2022 and a Saturday flight to Rhodes from 28 May to 29 October 2022.
Steve Heapy, chief executive of Jet2.com and Jet2holidays, said: "With many customers missing out on holidays over the past two years, we are seeing strong demand for summer 22, as more people look to book ahead and give themselves something to look forward to.
"As always, we have been quick to respond to demand by adding additional flights from Newcastle and Bristol airports, as well as launching a new and exclusive route from Bristol Airport, and offering customers and independent travel agents even more opportunity to book or enjoy some sunshine next summer."