In June and July, the operator will host five events in cities across the UK including Birmingham, Manchester, Glasgow, Newcastle and Leeds.
There are up to 120 places available, with spaces being allocated on a first-come, first-served basis.
The first event will take place at Dirty Martini in Birmingham on 21 June, followed by Dirty Martini in Manchester on 22 June, then Hummingbird in Glasgow on 28 June, The Social Club – Howlers in Newcastle on 29 June and Dirty Martini in Leeds on 6 July.
Alan Cross, director of travel agent relationships at Jet2holidays, said: "The Jet2holidays trade team is continuing to put partnerships at the heart of everything that we do, so we are delighted to be launching our ‘Big Night Out’ events to further cement these relationships with our independent travel agent and homeworker partners.
"The launch of these unmissable events demonstrates how integral these partnerships are to our business strategy and continued success."