Bellissima will finish its planned Red Sea itineraries homeporting in Jeddah on 26 March and then move to the Arabian Gulf to take over from Virtuosa from 2 April.
The vessel will then offer additional seven-night cruises calling in Dubai, Sir Bani Yas and Doha from 2 April through to 25 June.
Virtuosa, which has sailed the region since November 2021, will sail back to Europe to homeport in Southampton for the summer season.
In July, Bellissima will move to the Far East to perform its itineraries in Japan and China. Sales for the additional Bellissima cruises opened today.
The line said its Arabian Gulf sailings have proven to be "particularly attractive" to guests this winter, thanks to the "appeal of the itinerary" with extended stays in port and two overnights in Dubai.
Gianni Onorato, chief executive of MSC Cruises, said: "We have seen that the itineraries in the UAE and Qatar have been very popular with our guests and so to respond to this demand we have decided to extend our presence in the region.
"The decision to deploy MSC Bellissima for this extended part of the season was taken because this is a highly popular and well appreciated ship with a richness of features, entertainment and dining as well as offering the MSC Yacht Club."
