The move comes following the reopening of the Canadian and US borders. The operator has so far taken more than 70 customers to the destinations and plans to have taken more than 130 by the end of the year.
The first departures were three Canadian trips: Canadian Rockies, Canada’s Rocky Mountaineer and Canada - Niagara to the Rockies.
Customers were joined by senior long haul product manager Kathy Vigolo, who spent 14 days with the guests.
She said it was "an absolute delight" to accompany Newmarket’s first groups to Canada following the 18-month pause in operations.