Ethiopian said in a statement that it lost contact with flight ET 302 at 8.44am local time, after the aircraft took off from Addis Ababa, Bole International airport at 8.38am.
It is believed there were 149 passengers and eight crew onboard.
Search and rescue operations were in progress this morning, but the airline has since confirmed there are no survivors. The passengers were from 33 countries.
Ethiopian said in a statement posted at 1.46pm local time (10.46am UK time): “Ethiopian Airlines Group chief executive deeply regrets the fatal accident… The group chief executive who is at the accident scene right now regrets to confirm there are no survivors.