The new shop, which brings the East Anglia-based agency’s retail network to 26 stores, will welcome customers from early next month.
The branch, located in the Garden Square Shopping Centre, will be managed by Lucy Clarke, who has been with Premier for eight years and brings 21 years of travel experience to her new role.
The agency said it had chosen Letchworth for its “vibrant” independent businesses, adding the North Hertfordshire town was “seen as a perfect fit”.