The move comes after the airline announced plans to restart its Australia-UK route via Darwin once the country’s borders reopen on 1 November.
Qantas will lease Darwin airport’s Catalina lounge, which will have space for approximately 100 guests.
It will feature service delivered by local Qantas team members, lounge and dining areas, a buffet, a selection of wine, beer and non-alcoholic drinks and bathroom facilities.
Qantas group chief customer officer Stephanie Tully said the national carrier is "delighted" to work with the airport to "ensure a comfortable transit experience" for its business class guests.