Donation boxes will be located in the airport’s departures and arrivals halls allowing summer travellers to easily drop off their cash.
All proceeds will be split evenly between three charities - Alice House Hospice, the Great North Air Ambulance Service and the MFC Foundation.
Airport staff will also develop new fundraising ideas and offer support by volunteering to help the charities.
Tees Valley mayor Ben Houchen (pictured above) said the currency collection was “just the tip of the iceberg” in the airport’s charitable plans, with more events and activity being planned for the rest of the year.