The operator offers 40 hotels with daily non-stop flights from Heathrow and indirect options from airports including Manchester, Newcastle and Birmingham.
Tui’s expansion into city stays has grown from 121 hotels in five cities to 4,500 hotels in 62 cities over the past two years. In the US, San Francisco joins New York, Las Vegas, Miami, Boston, Washington, New Orleans and Chicago.
Tui UK & Ireland commercial and business development director Richard Sofer said: “The US market is really important for us as we grow our cities portfolio as we know how popular it is with customers.”