The initial plans were announced in September and the exact date of the reopening was confirmed a month later.
Arrivals will be required to show proof of full vaccination against Covid-19 and provide evidence of a negative Covid test taken up to 72 hours prior to departure, monitored by a health official via video link.
The ban was initially introduced in March 2020 by the Trump administration as the Covid-19 pandemic began to take hold.
To mark the global reopening, British Airways and Virgin Atlantic took part in a synchronised departure of two aircraft on parallel runways at Heathrow at 8.30am on Monday (8 November).
Sean Doyle, BA chief executive, said: "Today is our moment to celebrate the UK-US reopening. We’re setting aside rivalry and for the first time ever, British Airways and Virgin Atlantic aircraft will be seen taking-off together to mark the vital importance of the transatlantic corridor."