The company will host a 13-day Journey Through America’s Deep South tour, with stops in South Carolina, Georgia, Alabama, Mississippi and Louisiana from £5,195pp.
The price includes all accommodation, meals as per the itinerary and private transfers to and from the airport. First departure is 6 March 2022.
Travellers will be able to take a walk through Charleston led by a local history professor, discover the architecture and city squares of Savannah and sample a "jazz lunch" in New Orleans.
Wild Frontiers founder Jonny Bealby said the US has one of the most "diverse and complex cultural identities" in the world.
"For years we have considered how best to offer group tours to one of the largest countries in the world, and with the onset of the pandemic resulting in more limited travel corridors, we felt it was time to dedicate some much-deserved time and effort to this stunning country," he added.
"We feel this tour perfectly sits alongside our other offerings worldwide, combining stunning architecture and culinary delights with a land steeped in cultural conflicts and contrasting characters, all of which have played an integral part in the shaping of America’s past and present."