Services will initially operate on Tuesday and Saturday, with an additional Thursday flight from December. Wizz Air plans to operate the route five times a week from next April, with one-way fares from £39.99.
Wizz Air UK managing director Marion Geoffroy said: “We are delighted to be restarting our flights from London Luton to Tel Aviv, so that our customers can once again enjoy the delicious food, rich culture and breath-taking sights of the city.
“Whether it’s a short city break, a relaxing holiday over the Christmas period, or a trip to kick-start the new year, Tel Aviv has something to offer for everyone.”