It follows Inspiretec's sale to Spain's Juniper Group last November and its subsequent integration into Juniper's Taurus portfolio.
Powell, who founded the Cardiff-headquartered business in 1995 as Comtec, will be succeeded by long-serving Chief Commercial Officer Richard Baker.
Inspiretec provides backend tools and functionality to the travel trade – agents and tour operators – for managing content, customer data and sales processes.
The business said an orderly handover from Powell to Baker, who has been with Inspiretec for more than a decade, would ensure continuity and stability for customers and partners following the Juniper integration.
Powell is credited with leading Inspiretec through a period of "significant change". He will move on to focus on other business interests, including his AI start-up SystemsX.
“It has been a privilege to lead Inspiretec, and I am proud of what the team has achieved," said Powell. "With the business stable and well-placed for its next chapter, this feels like the right time for me to step down and turn to my other business interests."
Of Baker, he said: "Richard is the natural choice to lead Inspiretec forward. He knows our customers, our people and our technology intimately. The business will be in excellent hands.”
Baker said it was an honour to take on the leadership role at a business to which he devoted the past more than 10 years.
"My focus is firmly on continuity – the relationships our customers value, the people who deliver for them every day, and the roadmap we are committed to," he said. "We have a tremendous platform to keep building on."
Baker added: "I want to thank Simon for his leadership, and to reassure our customers and partners that what they value about working with Inspiretec will remain firmly in place."
Inspiretec recently recruited Sabre's Ric Corbett as its Business Development Director, tasked with driving new business growth, developing strategic partnerships and supporting Inspiretec’s continued expansion across the travel sector, while continuing to build on its reputation as an end-to-end technology platform for tour operators and travel agents.
