The design of the store on Bridge Street is based on the company’s successful shop in Madison Square, New York, and includes large LCD screens and interactive displays.
It also houses each of Flight Centre’s product ranges as well as its stand-alone brands.
The opening was attended by the Sheriff of Chester, councilor Alex Black, and the Lady’s Sheriff Janet Black.
Alison Zacher, retail managing director at Flight Centre UK, said: “At Flight Centre, we’re constantly striving to improve our store network and this new hyperstore is testament to that.