Jet2.com and easyJet are among the carriers to have proactively urged passengers to check the status of their flights before heading to their departure airports. Ryanair, meanwhile, has pre-emptively cancelled "a small number" of flights that had been due to overfly France.
It comes after the union representing workers across several sectors in France called a 35-hour strike over pay. The walkout will start from 6pm on Thursday (12 October) and run through to 5am on Saturday (14 October).
France’s aviation authority said Paris Orly would be the airport most severely affected, with 40% of flights cancelled, followed by Marseille (20%) and Beauvais (15%).
"While we are unsure of any disruption this may cause, there is a possibility of disruption to flights that are due to operate within French airspace," said Jet2.com in a statement.
"Our dedicated operations teams are working hard behind the scenes at our UK-based HQ to ensure any disruption is kept to a minimum."
ATC strikes have caused severe delays and disruption over the past few weeks, not only in the UK but across Europe too.
Ryanair has reiterated its plea to president of the European Commission, Ursula Von der Leyen, to protect overflights by ensuring minimum service levels in France.
“Ryanair calls on the EU Commission President, Ursula von der Leyen, to take urgent action to protect overflights and EU citizens’ freedom of movement during ATC strikes,” the Irish low-cost airline said.