From 14 February, those in the age bracket will be able to present a negative PCR test, or similar, taken within 72 hours of arrival to the country, as an alternative to proof of full vaccination.
All other UK travellers, excluding children under 12, will need to present a certificate showing proof of being fully vaccinated, with both doses of a two-dose vaccine or one dose of a one-dose vaccine, administered at least 14-days prior to arrival.
If more than 270 days have passed since the last dose was administered, proof of a booster jab is also required.
Prior to travelling to the country, all passengers must also present a QR code which is obtained from filling in the Health Control Form available via Spain Travel Health.
Spanish tourism minister Reyes Maroto said the country’s government is committed to making travel to Spain a "safe and easy experience" for its visitors.
"We hope that with these changes, many families will choose Spain to enjoy safe and memorable holidays together," he added.
Following the announcement, Steve Heapy, chief executive of Jet2.com and Jet2holidays, said the move tells families that travelling to Spain is "returning to normal".
"This is very welcome news for families who want nothing more than to holiday in their favourite Spanish destinations," he added.
"We are pleased to see the Spanish government taking positive action to welcome more arrivals from the UK and we know that this will lead to an increase in bookings.
"Our teams and colleagues are excited about welcoming millions of happy holidaymakers to their favourite Spanish destinations this year, and we look forward to more positive updates from the Spanish government."