The Italian carrier will operate 18 flights a week between London City and Milan Linate. This includes three daily services Monday to Friday, on on Saturday and two on Sundays.
Flights will get under way on 28 March. London City said the route would "kickstart" a summer turnaround after months of suppressed travel.
"London City airport today welcomes the return of flights to Milan Linate, as the city-centre hub seizes on pent-up consumer demand to revitalise its short-haul connections following the lifting of international travel restrictions."
