First implemented at the start of the pandemic in 2020, the initiative allowed the public to keep track of the spread of Covid-19 at sea.
But, on Monday (18 July), the CDC announced its programme for cruise ships is no longer in effect and its online hub will no longer be updated.
It said new guidance for cruise ships to mitigate and manage Covid-19 transmission will be available in the coming days.
A statement issued by the CDC added: "CDC has worked closely with the cruise industry, state, territorial, and local health authorities, and federal and seaport partners to provide a safer and healthier environment for cruise passengers and crew.
"Cruise ships have access to guidance and tools to manage their own Covid-19 mitigation programs. Additionally, cruise travellers have access to recommendations that allow them to make informed decisions about cruise ship travel.
"While cruising poses some risk of Covid-19 transmission, CDC will continue to publish guidance to help cruise ships continue to provide a safer and healthier environment for crew, passengers, and communities going forward."