The airline said it was quitting LBA to focus on maintaining and developing its "most popular" routes.
"Following a review of our routes from Leeds Bradford airport, we have made the decision to no longer operate flights from the airport after 5 January," said easyJet in a statement.
EasyJet currently flies to Barcelona, Belfast International, Majorca, Malaga and Paris from LBA.
Barcelona, Belfast and Paris flights are currently available to book until early January, and Majorca and Malaga flights until early November.
EasyJet has also previously offered seasonal services to Geneva, although none are currently listed on its website.
