The carrier will operate a seasonal Philadelphia service to Edinburgh, starting on 24 May.
Flights will depart Philadelphia ay 7.05pm, arriving in Edinburgh at 7am. Return flights will depart Edinburgh at 11.35am, arriving in Philadelphia at 2pm.
American will operate the route using a Boeing 787-8 aircraft. The seasonal service will run from late May through to October.
It is the first time American has operated to Scotland since 2019.
"Customer demand for flights to and from Europe continues to be strong as travellers seek to explore cities full of culture and history," said the airline’s vice-president international operation Jose Freig.