Further UK connections from Bristol and Leeds to San Francisco via Dublin will follow daily from 15 April.
The carrier will operate flights to the US city four times a week, increasing to a daily service from 26 March, with fares starting from £249 each way as part of a return trip.
The start of Aer Lingus Regional routes and resumption of the San Francisco service from Dublin will provide increased opportunities for UK regional customers to connect to Aer Lingus’ North American network, via its Dublin hub.
Daily flights to Los Angeles will also restart on 12 May and flights to Seattle will return five times a week from 26 May.
UK customers can now fly on 12 transatlantic routes via Dublin, including New York, Newark, Miami, Chicago, Boston, Los Angeles, San Francisco, Orlando, Washington, Seattle, Toronto, and Philadelphia.
Bill Byrne, Aer Lingus executive vice president US, said: "We are delighted to resume our Dublin to San Francisco service, connecting people from Birmingham, Manchester, Edinburgh, Glasgow, and London daily to West Coast USA from as little as £249 each way.
"With the convenience of US Customs and Immigration pre-clearance at Dublin, time spent connecting through Dublin provides customers with a speedier journey overall, as they arrive in the US as a domestic passenger."
