From this date, the Elizabeth Line will operate via new tunnels into the city. Until then, Heathrow Crossrail trains operate to and from Paddington.
Passengers from Heathrow will be able to travel east all the way to Abbey Wood in Kent. The link with Heathrow will open a day before World Travel Market begins at the ExCeL exhibition centre and services to Abbey Wood will call at Custom House, outside ExCeL.
Passengers travelling from Shenfield in Essex will be able to travel west all the way to Paddington and can change for trains to Heathrow or Reading on the same platform at any of the central London stations.
TFL said: “People landing at Heathrow airport will now be able to travel straight through central London to areas such as Farringdon and Canary Wharf in as little as 36 and 45 minutes respectively on the weekend and 40 and 51 minutes respectively during the week.”
The ramping up of services from 6 November means the Elizabeth Line will operate seven days a week, with Sunday services for the first time.
Ross Baker, Heathrow chief commercial officer, said: "This is a huge step in boosting rail connections to the UK’s hub airport directly linking Canary Wharf with Heathrow by rail for the first time.
“This gives our passengers and colleagues more choices to travel sustainably between Heathrow and London. I am delighted Heathrow will continue to be at the heart of a growing integrated transport network and our passengers and colleagues will reap the benefits."