President Luis Abinader made the announcement in an address to the nation, carried by all government social media channels.
Abinader said the onus would now be on individuals to take care and responsibility for themselves and others without restrictions.
He added that after a "long battle", the country and its people would now embark on a journey to "recover their freedom".
Key changes include scrapping any remaining mask mandates, easing social distancing rules and ending vaccine pass requirements.
