Flybe was one of the early casualties of the Covid crisis in early 2020, at which time it operated year-round to Newquay from Gatwick, Southend, Amsterdam, Edinburgh, Leeds-Bradford and Manchester airports.
It also offered seasonal connections from Belfast, Birmingham, Jersey and Guernsey.
However, starting 30 October, Flybe will return to Newquay offering a 12-times-weekly Heathrow service, flying double-daily on week days. It will also operate a daily Manchester service.
Flybe will operate both routes year-round using 78-seat Q400 aircraft.