The Friday flight launches in May to pair with the Monday flight currently in operation.
The operator said it was introducing the flight to offer more choices to consumers in the region.
Karen Switzer, director of aviation planning for TUI UK and Ireland, said: “We are delighted to be expanding our programme from Birmingham airport for summer 2018.
“We have added a Friday flight to Hurghada meaning we now fly twice a week to the Red Sea destination and with this additional flight customers can now book 10 or 11 night holidays.
“In total we have over 62 routes for customers to choose from when booking their holidays from Birmingham Airport.”