The airline will start flying three times per week from Manchester to Mumbai on 19 December with a twice-weekly route to Delhi due to follow on 5 January.
The Manchester flights will complement Virgin’s existing routes to the two Indian cities from Heathrow, which relaunched in September.
Juha Jarvinen, chief commercial officer at Virgin Atlantic, said: “We’re delighted to launch new flying from our home in the north in Manchester.