Virgin Atlantic is recommencing flights to Mumbai on 27 October after a four-year break.
The daily service from Heathrow will depart and arrive in the morning in the hope that customers will book accompanying flights to and from the US.
Flights will be operated onboard a Boeing 787-9 Dreamliner offering three cabin options: upper, premium and economy.
It comes after Virgin’s Indian partner, Jet Airways, suspended all flight operations last month.
Juha Jarvinen, executive vice-president commercial at Virgin Atlantic, said: “2019 marks a significant period of growth for Virgin Atlantic and I’m delighted we’re continuing to expand our route network once more by returning to Mumbai.
“Until recently, we’ve been able to serve this important market through our partnership with Jet Airways, however, since Jet Airways has sadly suspended its operation, we now have an opportunity to provide alternative options for our customers and meet this demand.
“Combined with our long-standing route to Delhi, we’re able to provide travellers even more opportunity to experience our award winning service between the UK and India.
“Not only are we providing an increased offering to the thriving Indian market, but together with our partners at Delta, we can offer unrivalled choice and more seamless connections to the US via Heathrow airport.”
Mumbai becomes Virgin’s fifth UK route announcement of the year.