Wizz Air will begin a new route from Luton to Sicily at the end of October and add two Eastern Europe destinations from Liverpool.
A twice-weekly flight to Catania will operate from Luton from 22 October, with one way fares from £17.99.
From Liverpool, Wizz will fly to the Moldovan capital Chisinau, also beginning 22 October, with single fares from £21.99. Flights will operate twice a week.
The airline will begin services to Cluj-Napoca in Romania a day later. Twice-weekly flights will be from £21.99.
The additions mean the airline will offer 71 routes from Luton and 11 from Liverpool.
Owain Jones, Wizz Air UK managing director said: “We are delighted to be introducing new low-fare connections to Liverpool John Lennon and London Luton, to provide our loyal customers the opportunity to explore three vibrant cities, whether it’s wine tasting in Chisinau, museum hopping in Cluj-Napoca or a romantic dinner in Catania.”