The Moroccan low-cost airline will operate twice-weekly flights on Thursdays and Saturdays from October utilising an Airbus A320 with one-way fares leading in at £60.
Once launched, the airport will be the only one outside London to feature flights operated by Air Arabia.
The airline’s group chief executive Adel Al Ali said: "We look forward to connecting Manchester with Agadir and we are confident that this step will further cater to the needs of our growing customer base.
“Agadir offers a great tourism experience year around with its unique beaches, mountains, golf resorts and excellent dining options".