The line’s Celebrity Eclipse will spend four months in the region, between December 2023 and April 2024, visiting 16 destinations.
The vessel will offer a 14-night Antarctica cruise and a 12-night Argentina and Patagonia sailing.
Guests wishing to visit Machu Picchu can book a 16-night repositioning cruise from Los Angeles to Chile, which includes two overnights in Lima and time to experience the Incan city.
Celebrity Cruises president and chief executive Lisa Lutoff-Perlo said: “The power of travel expands our horizons, introduces us to other cultures, and opens us up to truly fulfilling experiences.