The ship will homeport in four UK ports this summer, sailing a range of two-, three- and four-night voyages from Liverpool, Southampton, Newcastle and Tilbury.
Sailings will get under way on 15 July. Adult guests will be required to be fully vaccinated against Covid-19.
Disney said its multi-layered Covid health and safety protocols would also include testing, health screening, face coverings, reduced capacity, social distancing and enhanced cleaning.
It is also offering flexible booking options, covering changes and cancellations.
Entertainment will include "West End-quality" stage shows, with each sailing bringing to life classic Disney stories and characters, including Mickey Mouse, Minnie Mouse and their friends, the stars of Frozen, and Marvel’s superheroes.
Cruises from Liverpool will operate from 15-30 July, Southampton itineraries from 4-30 August, Newcastle from 3-11 September, and Tilbury from 14 September-1 October.
