The low cost carrier has based an additional aircraft at John Lennon airport - its eighth - for late summer and winter 2018.
Other new destinations include Palermo on Sicily and Pula in Croatia.
With flights operating twice a week, easyJet says it expects to carry more than 20,000 passengers to Palermo, Pula and Dalaman this summer.
The airline now serves 32 destinations from Liverpool.
Ali Gayward, easyJet’s UK country manager, said: “It’s great to announce these inaugural flights – we’re sure they will be popular with those looking for more choice of summer holiday destinations from the North West.
“The addition of another aircraft this summer will help us to deliver long term, sustainable growth at the airport while providing passengers with a greater range of destinations, all with low fares and great service.”
Paul Winfield, director of aviation development at Liverpool John Lennon airport, added: “The arrival of easyJet’s eighth aircraft here and the four new routes further demonstrates their commitment to the Liverpool market.
“EasyJet have also upgraded two of their A319 aircraft already based here to the larger A320 model, further increasing seat capacity.”