Almost 50 flights departed on Wednesday (15 July) from across Manchester, Birmingham, East Midlands, Leeds Bradford, Glasgow Newcastle and Stansted to destinations including the Canaries, Balearics, Turkey and Greece.
Flights will restart from Belfast International and Edinburgh on 16 July and 18 July.
The package holiday specialist will operate to 44 destinations this summer and is set to recommence services to Cyprus and Portugal on 1 August, with flights planned to Larnaca, Paphos, Faro, Madeira and Lisbon.
Other returns include the city break hotspots of Barcelona, Prague, Rome, Naples, Krakow and Amsterdam in September.
Jet2holidays released a video last week outlining new Covid-19 health and hygiene measures it will be employing to keep passengers and guests safe.
Chief executive of Jet2.com and Jet2holidays, Steve Heapy, said: “We have been saying for some time that the sun will shine again and that when it does, we will be there to take customers away on their well-deserved holidays. That day has finally arrived and we were delighted to see our first of flights take off.
"It is fantastic to be back in the air and recommencing our award-winning flights and package holidays to sunny destinations across Europe, the Mediterranean and the Canary Islands.
"The safety, wellbeing and comfort of our customers is our number one priority. Thanks to our three-step pledge, customers are in safe hands when they travel with us. Through our industry-leading customer service, customers know they can rely on us to deliver everything needed to make their holiday a happy and healthy one."
