Glasgow-based Loganair only started operating the route in November 2020 using a 49-seat Embraer jet – it had previously flown between London City and the Isle of Man for BA CityFlyer.
Loganair’s chief commercial officer Kay Ryan said: “We regret having to take this decision to cancel the Heathrow service and also very much regret the inconvenience to our customers.
“The sharp rise in costs of operating services at London’s premier airport coupled to the slower-than-expected rebound in passenger numbers after the pandemic mean that the route is not viable unless it has financial support from the Isle of Man government.