Flights between the city got under way on Monday (14 September) offering twice-weekly north-south connectivity.
Loganair then plans to extend the route to a daily service next March in the hope of capitalising on renewed demand for domestic breaks owing to Covid-19.
It is the latest in a string of former Flybe routes picked up by Loganair, with several other domestic carriers also helping rebuild UK domestic flight schedules.
Loganair will fly between Exeter and Newcastle on Mondays and Fridays, with fares leading in from £54.99pp one-way.
It will operate the route using a 49-seat Embraer 145 jet.
