The ferry operator is also planning to reduce the number of services between Dover and Calais, according to multiple media reports.
These moves are set to lead to a loss of around 140 jobs across the entire company.
The RMT union criticised the potential job losses and pointed out the £6.6 million in taxpayer funds received by P&O Ferries this summer to support its Hull routes. The Hull-Rotterdam route is set to continue.
RMT general secretary Mick Cash said: “This does not need to happen but P&O’s owners in Dubai have pulled the plug on this vital route with no consultation, threatening jobs, passenger services and the recovery of Hull’s maritime economy.”
P&O Ferries’ staff were told about the proposed closure of the Hull-Zeebrugge route on Wednesday (30 September) with two ships that operate on the route to be sold. Two vessels that sail the Dover-Calais route are also set to be offloaded.
“Due to the extended impact of Covid-19, we are having to take further difficult action in which some jobs will be made redundant - but as a result thousands more jobs will be saved,” said P&O Ferries in a statement.
"These necessary steps will ensure we are a slimmer and more agile business that is better able to give customers the service they want and the value they demand.”