Birmingham will see the highest number of new destinations with four routes to Bucharest, Milan Bergamo, Turin and Vilnius.
Bournemouth will benefit from two new Ryanair routes to Budapest and Wroclaw, while Bristol sees the introduction of services to Malaga and Barcelona in Spain.
The other new routes will be Cardiff to Dublin, Luton to Grenoble and Gatwick to Malaga, which will operate six times per week through the winter season.
Ryanair will operate a total of 400 routes over the coming winter including more than 2,000 flights per week until the end of March 2022.
