Flights to Seattle, Orlando and Cancun have been boosted by the addition of a new Airbus A332 aircraft.
The airline will flight to 13 destinations across the US, the Caribbean and Mexico from Manchester, Gatwick and Glasgow.
Some 720,000 seats will be on sale from Manchester for summer 2019, the airport’s largest long haul carrier.
Seattle will increase from two flights to three (mirroring San Francisco), Cancun enjoy daily departures and during peak season, Cook will operate 13 flights a week to Orlando.
Montego Bay in Jamaica is a brand new long haul destination for Cook.
Seattle and San Francisco lead in from £400 (£780 and £770 for premium), Montego Bay from £450 (£690 premium) an Cancun £510 (£710 premium).
Henry Sunley, Thomas Cook Airlines commercial director, said: “In the past two years, we have increased flights to destinations such as San Francisco, so we are pleased to grow Seattle following its inaugural flight earlier this year, and Orlando which we know is really popular with our customers.
“Strengthening our core fleet is a really important part of delivering great experiences for our customers, so we are looking forward to operating a new A332 in the long-haul programme next year.”
All economy fares include 23kg checked baggage, meal and in-flight entertainment.