The trip, which will depart on 20 May 2023, will take passengers from Cairo to Lisbon combining river journeys with land-based travel.
Ellen Bettridge, chief executive of Uniworld Boutique River Cruises, said: “We’re so proud to announce the inaugural Rivers of the World itinerary; our longest and most action-packed sailing to date spanning nine countries aboard five of our world-class super ships.
“It’s an itinerary like none other and a true holiday of a lifetime with surprises at every turn.”
