The six-minute film runs will through the safety instructions for BA flights, as well as introducing its Flying Start Charity, which supports Comic Relief.
The video features cameos from actors and TV personalities such as Gordon Ramsay, Rob Brydon, Sir Ian McKellen and Thandie Newton.
In a twist on the regular flight safety videos, 10 celebrities are seen auditioning in humorous sketches in front of comedian Asim Chaudhry for a coveted part in BA’s new safety video, while simultaneously demonstrating the safety features and procedures of the aircraft.
A longer version of this film will be shown on flights from September, replacing the current animated film, which has run for the past 12 years.
Alex Cruz, chairman and chief executive of British Airways, said: “It’s extremely important to us that customers engage with our safety video, and involving some of the nation’s most well-known personalities has given us the chance to create something fun that we hope people will watch from start to finish - and remember.
"We’ve worked with Comic Relief since 2010 and our customers have already helped us generate £16.5 million for great causes. We hope the new video will enable us to exceed our goal of raising £20 million by 2020."