The airline and operator has put 29 destinations on sale for summer 2026, with the first flight departing for Tenerife on 26 March.
Jet2 will base five brand new Airbus A321neo aircraft at Gatwick, flying to mainland Spain, the Canaries, the Balearics, Greece, Turkey, Portugal, Malta, Italy, Croatia, Bulgaria and Cyprus. A sixth aircraft based overseas will also serve the airport.
Jet2 said the decision to go into Gatwick would create more than 300 direct roles with Jet2, as well as "hundreds" more indirect roles.