A walkout is scheduled from 30 October to 2 November, affecting services to New York, Orlando and Barbados.
The dispute means that instead of flying direct with UK-based crew, passengers will fly from Manchester to Dublin and transfer to long-haul services there.
The strike follows a vote by 130 members of Manchester cabin crew, who are represented by the Unite union and who are employed on a different contract to their Dublin-based colleagues.
They have rejected a package offering a 9% pay rise this year and 3% next year, voting 90% in favour of action.
Unite said: "While they recognise this seems like a high number, the reality is that base salaries are so low workers have struggled to afford basics such as housing and bills.
"Many have also taken on second jobs or worked large amounts of overtime to try and make up for the shortfall in pay, leaving them at risk of stress and burnout."
The union told TTG action was “going ahead as it stands”.
Unite argues crew based in Manchester also have “far lower” flying allowances than their Dublin colleagues.
Aer Lingus has offered its Manchester workers an increase of $15 in the US overnight allowance to $130 (£97) but Unite said this “does not go far enough to address the imbalance”.
The union pointed out three executives, including the airline’s chief executive and chief financial officer, earned the bulk of almost €2.8 million last year.
TTG has approached Aer Lingus for comment.